192-195 In these sites, patients may present with airway obstruction, pain, epistaxis, facial deformity, unilateral otitis media, and orbital symptoms. SCSCC can occur anywhere in the head and neck region, including the nasopharynx, nasal cavity, and paranasal sinuses. The majority of SCSCCs, particularly of the larynx, occur in men (85%), most frequently in the sixth to eighth decades. SCSCC is also referred to as sarcomatoid carcinoma, pleomorphic carcinoma, metaplastic carcinoma, collision tumor, pseudosarcoma, and carcinosarcoma. Spindle cell squamous cell carcinoma (SCSCC) is a high-grade variant of SCC characterized histologically by the presence of differentiated SCC (in situ or invasive carcinoma) associated with a malignant spindle cell stromal component. WENIG, MARY RICHARDSON, in Modern Surgical Pathology (Second Edition), 2009 SPINDLE CELL SQUAMOUS CELL CARCINOMA Likewise a spindle cell melanoma is neurotropic only when its tumor cells prominently surround and/or infiltrate nerves, especially at the periphery of the tumor away from the main tumor mass.īRUCE M. A spindle cell melanoma is desmoplastic only if a significant part of its invasive tumor cell population is associated with and dispersed in a dense fibrous stroma. Although many desmoplastic and/or neurotropic melanomas are composed of spindle cells, they are not synonymous with spindle cell melanoma. Primary cutaneous spindle cell melanomas must be distinguished from miscellaneous sarcomas, in particular pleomorphic dermal sarcoma. Pure solid spindle cell melanomas are mentioned here separately to emphasize their heterogeneous composition as well as the related differential diagnosis. Spindle cell features may be seen in the invasive component of various melanomas (lentigo maligna, acral, superficial spreading, nodular). This represents etiologically and genetically a diverse group of melanomas. Spindle cell melanoma refers to invasive melanomas in which the tumor is predominantly or exclusively composed of spindle cells. Scolyer, in Pathology of Melanocytic Tumors, 2019 Spindle Cell Melanoma
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